The topic of 'affair' is central to several of the podcast episodes provided, with the episodes delving into various cases where an affair or extramarital relationship was a key factor in the crimes or events discussed.

For example, in the episode 'The Killer In The Attic', the affair between Dolly Oesterreich and her teenage employee Otto is a key aspect of the case, leading to the murder of Dolly's husband Fred. Similarly, the episode 'The FBI Killer - Susan Daniels Smith' focuses on the affair between FBI agent Mark Putnam and his informant Susan Smith, which ultimately resulted in her murder.

The episode '#302: TikToker Killed 2 People To Help Hide Her Mom's Affair & Save Her Career' also explores the consequences of an affair, with Ansreen's affair with Saqib leading to a series of events that resulted in multiple deaths.

Across these episodes, the topic of affair is shown to be a significant factor in the crimes and events discussed, often serving as a catalyst or driving force behind the actions taken by the individuals involved.