The topic of AI Safety and Security is extensively covered in the podcast episodes, highlighting the potential risks and vulnerabilities associated with AI systems.

The formation of the U.S. government's AI Safety and Security Board is a key focus, as it aims to advise on protecting critical infrastructure from potential AI disruptions and help stakeholders use AI responsibly. This is in line with the Biden administration's efforts to regulate AI.

The episodes also discuss the concerning discovery of the 'Skeleton Key' technique, which can bypass safety measures in multiple generative AI models, potentially allowing harmful or restricted information to be extracted. This demonstrates the need for robust safety measures and security protocols as AI technology continues to evolve.