The podcast episodes provided touch on various aspects of the American South, from its complex racial history and the legacy of the civil rights movement to its distinct cultural identity and economic development.

For example, the episode 'Episode 578: Clementine Barnabet & The Church of the Sacrifice & The Louisiana Axe Murders' examines the racially-charged violence and injustice that occurred in the region during the early 20th century, while 'Grief, Racism, and the Climate Crisis (w/ Mary Annaïse Heglar)' explores how the region's history and culture have shaped the modern environmental movement and climate justice efforts.

Likewise, the episode 'How Unions Won The South' delves into the complex and often contentious history of labor unions in the American South, a region that has long been considered resistant to organized labor, while 'Presenting Gone South Season 2: The Dixie Mafia' sheds light on the criminal underworld that thrived in the region during the mid-20th century.