The topic of apostasy, or the formal abandonment of one's religion, is relevant to the podcast episodes provided.
In the #356 - Islam & Freedom episode, the treatment of apostates who leave Islam is a major point of contention regarding Islam's alleged uniqueness compared to other religions.
Similarly, in the The Death of Cringe (LOL Cows are Boomer) episode, Simone speculates that future targets of online mockery may include apostates from religious or political movements.