The podcast episodes discuss the use of brain imaging techniques, such as fMRI, PET scans, SPECT scans, and magnetic resonance spectroscopy, to study the effects of various factors on brain activity and structure.

The episodes cover a range of topics, including the neuroscience and philosophy behind psychedelic experiences (Luminous: Your Brain on Shrooms), the use of brain imaging in the diagnosis and treatment of conditions like autism (386: Why Autism Is on the Rise and How to Treat It Holistically (What Every Parent Needs to Know!) | Suzanne Goh, MD), the impact of menopause on cognitive health (Top Brain Expert Reveals Why Women Are More At Risk of Alzheimer's & Cognitive Decline and What They Can Do to Prevent It with Dr. Lisa Mosconi), and the role of brain imaging in understanding and promoting overall brain health (Psychiatrist Dr. Daniel Amen On All Things Brain Health, Dementia, Alzheimer's & ADHD, Change Your Life with Celebrity Brain Expert Doc Amen | E46, What makes you behave the way you do? Lis Hoekstra l Billy Carson interview Dr. Daniel Amen).

The episodes also discuss the importance of the neurotransmitter glutamate and its role in brain function and neurological disorders (Episode 163: Mark Mattson discusses glutamate, the brain's most important neurotransmitter).