The concept of brain plasticity is a central theme across the podcast episodes discussed, as it underpins many of the topics explored, such as the cognitive abilities of birds, the impact of exercise and lifestyle on brain health, and the mechanisms behind willpower and tenacity.

Several episodes highlight how the brain's plasticity enables it to grow, shrink, and form new connections, facilitating learning, memory formation, and adaptation. For example, the Bird Brains episode examines how the unique brain structures and organization of birds allow them to exhibit complex cognitive abilities, while the The Exercise Neuroscientist episode discusses how physical activity and social connections can enhance brain plasticity and prevent cognitive decline.

The role of brain plasticity is also discussed in relation to topics like dreaming, time perception, and the impact of technology and social media on brain function, as explored in the From the Vault: Inner Cosmos, with David Eagleman episode.