The COVID-19 pandemic and the subsequent implementation of vaccine mandates have been central topics of discussion in the podcast episodes, with the hosts and guests sharing their personal experiences, perspectives, and the impact on their respective fields.

For example, in The Joe Rogan Experience #2168 - Tyler Fischer, the conversation covers Fischer's experiences during the COVID-19 pandemic and the controversies surrounding vaccine mandates, including the controversy surrounding Dr. Anthony Fauci's emails. Similarly, in Ep 477 - Father God (feat. Cole Beasley) of Matt and Shane's Secret Podcast, the COVID-19 pandemic and vaccine mandates were a central topic of discussion, with the hosts and guest Cole Beasley sharing their perspectives and experiences related to the NFL's protocols and Beasley's stance against the mandates.