The podcast episodes provided utilize dark humor and satire to examine a range of disturbing topics, from true crime and domestic violence to slavery and police incompetence.

For example, the 'My Favorite Murder' episode MFM Minisode 390 employs the hosts' signature blend of dark wit and macabre fascination when discussing their listeners' hometown stories, while the 'Women Talkin' 'Bout Murder' episode Wife Killer satirizes the true crime genre through a fictionalized interview with a charming serial killer.

Similarly, the 'Last Podcast on the Left' episode Side Stories: The Death of OJ Simpson applies irreverent, darkly humorous commentary to a range of unsettling news stories, from celebrity deaths to medical mishaps.