The podcast episodes explore various defense strategies employed in high-profile criminal cases, such as challenges to DNA and other forensic evidence, attempts to sway juries, and efforts to delay or derail trials.

For example, the episode PREVIEW: #NONNUCLEAR MISSILES discusses defensive strategies against non-nuclear missile threats, while the episodes Kouri Richins speaks. Karen Read's lawyer goes to work. And Bryan Kohberger still has no trial date and The Art of Jury Selection (with Mimi Rocah) examine defense tactics like jury selection and challenging the admissibility of evidence.

The episode No Body, No Problem: Guilty Verdict Reached in the Presumed Murder of Jennifer Dulos also explores how the defense tried to pursue a trial after a key defendant's suicide, highlighting the variety of strategies employed by legal teams.