The topic of 'Denying Self' is central to the podcast episodes, which emphasize the importance and difficulty of denying one's flesh and desires as a disciple of Christ.

In the episode 'Destiny & Direction (Larry Brey)', the speaker discusses how our destiny is determined by a decision, but direction requires a daily denial of ourselves. Similarly, in the episode 'I Know a Friend who Knows a Friend', the host shares personal examples of her struggles with denying her own flesh and desires as a Christian.

These episodes highlight the ongoing process of denying self and the challenges believers face in this journey of discipleship.