The podcast episodes provided cover a range of disease outbreaks, including those related to infectious diseases such as HIV/AIDS, Ebola, COVID-19, measles, and meningococcal meningitis, as well as broader issues surrounding disease outbreaks like government response, public communication, and pandemic preparedness.

For example, the episode '1011: Dr. Anthony Fauci | The Science and Politics of Public Health' features an interview with Dr. Anthony Fauci discussing his experiences managing major disease outbreaks, while the episode 'Ep. 38 | After the Bell' focuses on the investigation and containment of a meningococcal meningitis outbreak in an elementary school.

The episodes also touch on the impact of environmental factors, such as the link between climate change and the dengue fever outbreak in Brazil reported in 'Landslides and massive flooding kill nearly 60 in Brazil', as well as the potential for animal-to-human disease transmission, as discussed in the episode 'TBD | Bird Flu-It's in Milk?' about the outbreak of bird flu in U.S. dairy cows.