The podcast episodes provided cover the use of cutting-edge DNA analysis techniques in solving complex criminal cases, particularly long-unsolved murders.

For example, the episode 'Facing the Music' discusses how investigators were able to finally identify the killer of Christy Mirack using genetic genealogy and phenotyping, technologies that can infer physical traits from DNA.

Similarly, the episode 'Evil Walked Through the Door' demonstrates how DNA evidence and investigative genetic genealogy were key to linking and solving two murders in Toronto decades apart.

The 'Case 282: April Tinsley' episode also highlights how DNA played a pivotal role in the investigation into the abduction and murder of a young girl, with samples from the original crime scene in 1988 and later letters from the killer used to identify the perpetrator.