The episode mentions Amanda's use of marijuana and her suspected theft of her pot dealer's weed, which may have been a contributing factor to her murder.
Tyler's drug abuse, specifically taking ecstasy before the murders, is mentioned.
Taylor's drug use, including meth and antidepressants, is cited as a factor that may have contributed to her disturbing actions.
Drug abuse is a prevalent theme throughout the podcast episodes, with numerous examples of individuals engaging in the abuse of a wide range of substances, including prescription medications, illicit drugs, and even everyday household items.
Several episodes delve into the role of drug abuse in fueling criminal behavior, dysfunctional relationships, and tragic outcomes, such as Ashley's battle with heroin and cocaine addiction, the narrator's boyfriend and his mother's involvement with drugs, and Taylor Schabusiness' reported abuse of meth and antidepressants.
The podcasts also explore how drug abuse can intersect with mental health issues, as seen in the case of Austin Harrouff's hallucinogen and amphetamine use, and how it can contribute to the breakdown of family dynamics, as exemplified in episodes like the 'Incest Torture Van' story.