Drug addiction and substance abuse are central themes in several of the podcast episodes provided, highlighting the personal struggles and experiences of individuals dealing with these issues.

The first episode, The Criminal Conviction of Hunter Biden, focuses on Hunter Biden's federal gun charges related to lying about drug use, illustrating how substance abuse can intersect with the legal system.

The second episode, E483 Billy Strings, features the bluegrass musician Billy Strings discussing his personal experiences with various substances, including methamphetamine, crack cocaine, and psychedelics, and his journey to sobriety and success.

The third episode, Rethinking Crime and Punishment With San Francisco's Mayor, touches on the need to address the fentanyl crisis and provide treatment options for individuals struggling with drug addiction as part of a broader discussion on addressing crime and homelessness in San Francisco.