The podcast episodes provided discuss drug experiences in various contexts, from the paranoia associated with a high dose of edibles to the personal anecdotes and banter around the use of cocaine, crack, and other substances.

For example, in episode 76 of "We're Here to Help", the caller shares his experience of taking a high dose of edibles and the paranoia that followed. Similarly, in #445 of "The Basement Yard", the hosts discuss their experiences witnessing drug use, such as cocaine, crack, and horse tranquilizers.

In #2123 of "The Joe Rogan Experience", the host and guest briefly discuss their experiences with various substances, including marijuana and psychedelics, and the potential risks and benefits associated with them.