The podcast episodes explore the topic of extinction from various perspectives, including the historical and cultural significance of extinct species, the causes and consequences of extinction events, and the potential for conservation and de-extinction efforts.

The episodes highlight the importance of understanding extinction in the context of environmental change, human impact, and the complex relationships between species and their habitats. They also delve into the philosophical, ethical, and epistemological implications of extinction, exploring how our perspectives on extinction shape our understanding of the natural world and our place within it.

For example, the episode 'Animal, Episode 5: Wolves' examines the cultural significance of the extinct Japanese wolf and the impact of its loss on the natural and cultural heritage of Japan. The episode 'Joshua Schuster, "What Is Extinction?: A Natural and Cultural History of Last Animals"' explores the changing definitions and representations of extinction across various disciplines, from environmental humanities to media studies. The episode 'Thom van Dooren, "The Wake of Crows: Living and Dying in Shared Worlds"' focuses on the complex relationships between humans and crows, and the implications of species conservation and extinction for multispecies ethics.