The podcast episodes explore various aspects of the fentanyl crisis, including how drug dealers are lacing recreational drugs with fentanyl to increase profits, despite the deadly consequences for users. Episode 1517 of Reply All investigates the economic factors driving this practice, while Episode 47236 of Psychiatry & Psychotherapy Podcast emphasizes the need for tailored treatment approaches to address the challenges and risks associated with fentanyl misuse.

The episodes also cover the broader opioid epidemic, discussing the historical roots, the neurobiology of addiction, and various treatment approaches, with fentanyl's role in exacerbating the crisis being a recurring topic. Episode 47371 of Psychiatry & Psychotherapy Podcast provides a comprehensive overview of the opioid epidemic, including the rise of fentanyl.

Additionally, Episode 61181 of The Checkup with Doctor Mike features a discussion on the potential benefits of legalizing and regulating all drugs, including fentanyl, as a means to reduce drug-related harms and deaths.