The podcast episodes cover various aspects of global development, including strategies for driving positive change in areas like health, education, and climate change.

For example, the episode "#189 - Rachel Glennerster on how 'market shaping' could help solve climate change, pandemics, and other global problems" discusses the potential of 'pull mechanisms' like advance market commitments to incentivize socially beneficial innovations, which could have a significant impact on global development outcomes.

Other episodes touch on topics like crisis management in humanitarian aid "127. Rajiv Shah Never Wastes a Crisis", empowering women through access to information "When you inform women, you transform lives | Paige Alexander", and the role of community health workers in improving healthcare access "S15 Ep7: Episode 5: Johnson & Johnson Centre for Health Worker Innovation presents 'The Point of Care Around the World' in association with The Conduit".