The podcast episodes presented explore the theme of guilt and self-doubt, as characters grapple with the consequences of their past actions and decisions, particularly in the context of rescue efforts and personal relationships.

In the episode of The Archers, the characters express feelings of guilt and self-doubt regarding their roles in past rescues and the potential consequences for Alice's involvement in a crash. Similarly, in the episode of Therapy Gecko, a caller details her harrowing experience marrying a stranger, leading to self-doubt and a tendency to lose interest in relationships.

These examples illustrate how guilt and self-doubt can manifest in various aspects of life, from professional responsibilities to personal relationships, and the impact these emotions can have on an individual's well-being and decision-making.