The podcast episodes cover various aspects of healthcare advocacy, including efforts to address issues such as overregulation, physician burnout, access to care, and policies around pain management and opioid use.

For example, the episode Pain Relief: New approaches to how we live with pain explores new understandings of pain and alternatives to opioids, featuring insights from a chronic pain sufferer, a physician researcher, and an opioid reform advocate. The episode Jimmy Kimmel discusses Kimmel's advocacy for healthcare, stemming from his personal experience with his son's health condition and the impact it had on public discourse.

The episodes also highlight the role of healthcare systems, such as Novant Health, in advocating for policy changes and amplifying clinicians' voices to inform policymakers, as seen in the episode Pam Oliver, Chief Medical Officer of Novant Health. Additionally, the episode Medicare Advantage plans on the rise, and under scrutiny examines the advocacy efforts of groups and lawmakers to address issues with Medicare Advantage plan practices.