The podcast episodes discuss hoarding behavior in various contexts, from the hoarding tendencies of serial killers like Herb Baumeister to the impact of hoarding on personal relationships.

For example, in Episode 568: Herb Baumeister Part I - The Bone Twins, the episode details how Baumeister's hoarding of items like refrigerators and pressure washers was part of the investigation into his crimes. Similarly, in My Husband Has Pictures of Naked Women, a significant portion of the episode addresses the wife's hoarding problem and its effect on the couple's home and family.

The episodes also explore the connection between wealth, extravagance, and hoarding, as seen in #211: The Millionaire "Human Girl" Collector & Sex Dungeons, which discusses the disturbing case of a millionaire who hoarded various items in addition to his criminal activities.