The topic of human extinction is explored in the podcast episodes, which examine the potential existential threats that could lead to the complete demise of the human race.

Several episodes, such as Episode 6 - Shut it down?, The Best Pronatalist Comedy We Have Seen (Julie Nolke), and X-Risk: How Humanity Discovered Its Own Extinction, discuss the risk of human extinction, including the dangers posed by the development of advanced artificial intelligence, demographic collapse, and other existential crises.

The podcasts explore the contrasting perspectives on the future of humanity, from Eliezer Yudkowsky's dire warnings about the potential for superintelligent AI to cause human extinction, to more optimistic views on how powerful but constrained AI could greatly benefit humanity if developed responsibly.