The podcast episodes highlight the concept of human insignificance in the grand scheme of the cosmos, particularly the feeling of being overwhelmed by the sheer scale and magnitude of the universe.

In the episode "OUTER SPACE HAS RUINED MY LIFE", the host discusses an "amateur astronomer" who is immobilized with anxiety due to the vastness of the cosmos, reflecting on the theme of cosmic insignificance.

Similarly, the episode A Veteran Eclipse Chaser Explains the Thrill of Totality explores how the experience of a total solar eclipse can evoke a profound sense of connection to the vastness of the universe, leaving the viewer with a feeling of insignificance in the face of such cosmic events.