The podcast episodes discuss various issues related to the Iran nuclear deal, including U.S. foreign policy towards Iran, the impact of the deal on regional dynamics, and political debates surrounding it.

For example, in Episode 1993 of The Ben Shapiro Show, there is discussion of how Iran may accelerate its nuclear program if Trump appears likely to win the presidency. In Episode 5/23/24 of the Mark Levin Podcast, Levin exposes the Obama/Biden administration's interference in preventing the FBI from arresting individuals involved in Iran's nuclear program during the deal negotiations.

The episodes also highlight criticisms of the Biden administration's approach to Iran, including accusations of appeasing Iran and undermining U.S. allies like Israel in pursuit of a new nuclear deal.