The lack of physical evidence is a recurring theme in the podcast episodes, as it can make investigations and prosecutions extremely challenging, even for high-profile cases.

In the case of the disappearance of Danielle Imbo and Richard Petrone, the investigators had no physical evidence to work with, which added to the mystery and difficulty of the case. Similarly, in the Natalee Holloway case, the lack of physical evidence tying the prime suspect to the crime was a major obstacle in securing a conviction, Episode 562: The Murder of Natalee Holloway.

The podcast episode on the alleged police sex cult, #212: The Police Sex Cult That Sacrificed 25 Babies During Rituals, also discusses how the lack of physical evidence to corroborate the extensive allegations raised doubts about the veracity of the claims.