The podcast episodes explore the theme of loss in its various forms, from the loss of a loved one or the end of a meaningful relationship, to the loss of dreams, plans, and even one's sense of self.

The episodes provide intimate and moving accounts of the emotional impact of loss, the grieving process, and the strategies individuals employ to navigate this difficult terrain. Through personal narratives and reflections, the podcasts offer insight into the universal human experience of loss and the resilience required to move forward.

Specific episodes that delve into this topic include 1148: Urine Season by Niina Pollari, which explores the emotional toll of profound loss, and Grief | Girls Gone Bible, which examines grief through the lens of faith and community. Other episodes, such as Grief: How to Move Through Losing a Friend with Sloane Crosley and EP10: Reflecting on Grief, provide deeper explorations of the grief process and the challenges of coping with the loss of a loved one.