The podcast episodes discuss various aspects of mate selection, including the evolutionary origins of human mating strategies, mate preferences, attraction, and the differences between short-term and long-term mating approaches.

For example, episode 39650: "Monster Girls & Evolutionary Biology" explores the prevalence of "monster girl" fetishes and how certain physical traits may have evolved due to mate selection. Episode 16280: "Andrew Tate's Plan to Fix Fertility Rates" contrasts the hosts' views on careful mate selection for cultivating desired traits in offspring with Tate's approach of maximizing fertility rates.

The episodes featuring evolutionary psychologist David Buss, #282 - David Buss: Sex, Dating, Relationships, and Sex Differences and Dr. David Buss: How Humans Select & Keep Romantic Partners in Short & Long Term, provide in-depth discussions on the science behind human mate selection strategies, including the criteria used for short and long-term partners, the causes of infidelity, mate retention tactics, and the darker aspects of mating behavior.