The podcast episodes discuss various situations involving medical examinations or procedures, where the human body and its quirks or complexities can lead to embarrassing or humorous moments.

For example, in The Moth Podcast: Funnybone, the stories explore embarrassing experiences during a sleep study and an overprotective mother's reaction to her daughter's doctor's appointment.

Similarly, in Armchair Anonymous: Greatest Fear, a caller shares an embarrassing encounter at the dermatologist, highlighting the vulnerability often associated with intimate medical examinations.