The podcast episodes in the 'MrBallen's Medical Mysteries' series provide detailed accounts of medical investigations and the vital work of doctors, scientists, and public health officials in uncovering the root causes of various health issues.

From the Ebola outbreak in Zaire in the 1970s ('River of Blood') to the pellagra epidemic in the American South ('Scourge of the South') and the mysterious illness linked to a contaminated supplement ('Deadly Cramp'), these episodes demonstrate the rigorous research, testing, and collaboration required to solve medical mysteries and implement effective public health measures.

The podcast also highlights the importance of patient advocacy, medical ethics, and the impact of regional poverty and malnutrition on public health.