The podcast episodes provided focus on cases involving murder-for-hire schemes, where individuals have orchestrated the killing of others, usually through the use of hired assassins or hit men.

For example, in the episode Introducing: There and Gone: South Street, the FBI suspected the disappearance of Danielle Imbo and Richard Petrone was a case of murder-for-hire. Additionally, the episode Talking Dateline: The Road Trip details how Teresa Sievers was killed by men hired by her husband Mark to commit the murder while he established an alibi out-of-state. The Amy Allwine episode also centers on a murder-for-hire plot orchestrated on the dark web.

These cases highlight the complex and often disturbing nature of murder-for-hire, where individuals go to extreme lengths to arrange the deaths of others, sometimes for personal reasons or financial gain.