The concept of natural selection, as described by Charles Darwin, is central to the podcast episodes discussing topics related to evolutionary biology and genetic adaptation.

In the first episode, the host Tim Pool references ideas from evolutionary psychology and natural selection in the context of discussing gender dynamics. This suggests that natural selection plays a role in shaping human social behavior and characteristics.

The second episode, Wolves Are Thriving In The Radioactive Chernobyl Exclusion Zone, focuses on how natural selection has favored genetic variations in gray wolves that have allowed them to survive and thrive in the high-radiation environment of the Chernobyl exclusion zone, demonstrating the power of natural selection to drive adaptations to extreme environmental conditions.