The podcast episodes provided focus extensively on the topic of obsessive-compulsive disorder (OCD), exploring various aspects of this mental health condition.

Several episodes feature personal stories and insights from individuals who have struggled with OCD, such as Breht's lifelong struggle with OCD, Alegra Kastens' experience as a therapist working with OCD patients, and author John Green's portrayal of OCD in his novel 'Turtles All the Way Down'.

The episodes also address the importance of proper diagnosis and treatment of OCD, including the role of cognitive-behavioral therapy (CBT), mindfulness, and exposure therapy, as well as the need to destigmatize this often misunderstood disorder. For example, Allison Raskin discusses navigating relationships and coping mechanisms while living with OCD.

Some episodes, such as the one featuring Dr. Katharine Phillips, draw comparisons and contrasts between OCD and related conditions like body dysmorphic disorder (BDD). Others, like the Huberman Lab AMA episode, clarify the distinction between true OCD and casual use of the term.