The podcast episodes delve into the various theories and speculations surrounding the origins of the universe, including the Big Bang theory, the possibility of multiple universes, and the role of quantum mechanics in the early universe.

For example, the episode Quantum Quandaries and Cosmic Contemplations with Sean Carroll explores how quantum mechanics and classical physics differ, and the profound implications these concepts have on our understanding of the universe, including the origin and evolution of the cosmos. Another episode, Ep. 1: The First Fraction of a Second, focuses on the specific details of the early universe, such as the period of cosmic inflation, the quark-gluon plasma, and nucleosynthesis in the first few minutes after the Big Bang.