The central focus of the episode is exploring the origins and history of humans keeping animals as household pets.
The concept of Petsby is centered around pets, as it allows pet owners to share content from their pets' perspectives, fostering a sense of anthropomorphism.
Pet-related stories and mishaps, particularly involving cats, are a recurring theme throughout the episode.
Mari discusses how caring for her new puppy Arnold motivates her morning routine and brings her joy despite the responsibilities.
The hosts discuss their experiences with pets, including fostering animals, concerns about adopting new pets, and their relationships with their current pets.
The loss of beloved pets is discussed, with Martin sharing his personal experience of losing his dog Jesse and the ways his family memorialized her.
The podcast episodes cover a wide range of topics related to pets, including the history and origins of pet-keeping, the unique bonds between humans and their animal companions, the challenges and joys of pet ownership, and the various roles pets play in people's lives.
For example, the episode "When did people start having pets?" explores the domestication of dogs and cats and the evolution of the human-pet relationship over time. Meanwhile, episodes like "Optimize Your Morning Routine + Taking Mushrooms & Vacation Adventures" and "Phil Robertson's Fastball Once Knocked a Kid's Eye Out!" discuss how pets can impact and motivate people's daily routines and personal experiences.
Other episodes, such as "87 - RACHEL STERLING" and "EP. 13 Behind the Scenes with Madison Beer: Exploring Silence Between Songs plus Q & A", feature pets making appearances and being part of the hosts' or guests' lives, highlighting the significance of pets in modern society.