The city of Philadelphia features prominently in several of the podcast episodes provided, with the city's history, culture, and notable events serving as key settings and topics of discussion.

For example, the episode "Introducing: There and Gone: South Street" delves into the mysterious disappearance of Danielle Imbo and Richard Petrone, which took place in Philadelphia, while the "The Bolber-Petrillo Murder Ring Pt. 2" episode chronicles the crimes of a notorious insurance fraud ring that operated in the city in the 1930s.

Other episodes, such as "WWDTM: Christian McBride" and "'Creed' Live From Philly With Bill Simmons, Chris Ryan, Sean Fennessey, and Van Lathan", explore Philadelphia's cultural and artistic identity, including its music scene and role in the Rocky film franchise.

Overall, Philadelphia's rich history, diverse communities, and status as a hub for various industries and cultural events make it a recurring and significant topic across the podcast episodes provided.