The podcast episodes focus on prion diseases, which are rare and fatal neurodegenerative disorders caused by the misfolding of proteins in the brain.

In the first episode, Sonia Vallabh shares her personal mission to find a cure for the prion disease she is genetically predisposed to, gaining insights into the brain's vulnerability and the urgency to find treatments. The second episode explores new potential treatments for deadly prion diseases entering clinical trials, as well as related research on the environmental impacts of farming methods.

These episodes highlight the challenges in studying and treating prion diseases, and the critical need for research and therapeutic development in this area.