The concept of 'sacrifice zones' is a recurring theme in the podcast episodes, particularly in relation to the Ohio River Valley and Cancer Alley regions.

In the episode 'Petrochemicals and Plastics: A Fossil Fuel Lifeline?', the podcast explores how these 'sacrifice zones' are impacted by the fossil fuel industry's shift towards petrochemicals and plastics, and the efforts of activists fighting for environmental justice.

Similarly, the episode 'Lesson 7: Do It Again' chronicles the community-led battle against the Byhalia crude oil pipeline in Memphis, which revealed deeper environmental injustices and prompted activists to broaden their fight against systemic racism and for healthy neighborhoods.