The podcast episodes discuss numerous cases of people who have mysteriously vanished, with a significant focus on the extensive search and rescue operations that have been conducted in an attempt to locate them.

Several episodes, such as Status: Untraced - E3: The Legend You Live, He Vanished Mysteriously From His College Apartment… Where Is Caleb Harris?, Vanished Into Thin Air!? What Happened to 21-Year-Old Layla Santanello…, and #312: Help Us Find Nancy - 12 Went To Yoga Retreat Only 11 Returned & Nobody Will Tell What Happened, provide detailed accounts of the search and rescue efforts undertaken by law enforcement, family members, and volunteers in response to the disappearances.

The episodes also touch on the challenges and frustrations faced by the families and investigators in these cases, such as uncooperative witnesses, lack of evidence, and the vastness of the search areas.