The importance of self-advocacy in healthcare is a central theme that emerges from the podcast episodes, with the hosts emphasizing its impact on improving medical experiences and outcomes.

In the episode 'Zach Kornfeld Tries Medicine Without A Recipe', Zach Kornfeld and Doctor Mike discuss the challenges of navigating the U.S. healthcare system, including Zach's personal struggles with chronic conditions and the need to take an active role in his own care.

Similarly, in the episode 'Let's Get Physical and Anxious', the hosts Katie Dalebout and Serena Wolf highlight the importance of self-advocacy, particularly for women, to ensure their concerns are adequately addressed during medical appointments.