Sickle cell disease is a genetic disorder that affects the red blood cells, causing them to become sickle or crescent-shaped instead of the normal round shape. This abnormal shape can cause the cells to get stuck in small blood vessels, blocking blood flow and oxygen supply to tissues.

As a result, people with sickle cell disease can experience a range of complications, including episodes of severe pain, organ damage, and increased risk of infections. The condition is particularly prevalent among people of African descent, as the sickle cell trait provides some protection against malaria, which is common in sub-Saharan Africa.

The podcast episodes discuss the promising developments in gene-editing therapies, such as the CRISPR-based treatment Casgevi, which has the potential to revolutionize the treatment of sickle cell disease and improve the lives of those affected by this debilitating condition.