The concept of Soul Binding, where a portion of the Emperor's psyche is bound into psykers, is a key topic explored in the podcast episodes provided.
In Episode 40281 of Critical Role, the Bells Hells encounter Aeorian terrors as they explore the ruined city and seek out the wrinkle in Ludinus' plans, which involves revelations about Dominox's soul being bound or anchored to a mystical 'engine'.
The Episode 36 of The 40k Lorecast delves into the process of Soul Binding, where the Imperium forces a portion of the Emperor's psyche into psykers to purge Chaos corruption, which is a critical aspect of the Imperium's handling of psykers.