The podcast episodes cover several topics related to the role of state regulations, including employer-provided childcare, youth employment, chemical labeling laws, and the implementation of road safety initiatives.

For example, the episode 'How Employer-Funded Child Care Can Work' discusses how state regulations around childcare facilities can complicate the implementation of employer-provided childcare benefits, especially for companies operating across multiple states.

Another episode, '572- WARNING: This Podcast Contains Chemicals Known to the State of California to Cause Cancer or Other Reproductive Harm', explores how California's Proposition 65, a state-level law, has played a role in addressing toxic exposure in the absence of robust federal regulations.

The topic of state regulations also arises in the context of road safety initiatives, as seen in the episode 'What Vision Zero Has And Hasn't Accomplished', where the role of state regulations in hindering cities' efforts to implement measures like lowering speed limits is discussed.