The Holocaust is a central theme across multiple podcast episodes, as it explores the devastating impact of the Nazi regime's persecution and mass murder of Jews and other targeted groups during World War II.

Several episodes delve into the historical context and consequences of the Holocaust, including how it influenced the strengthening of US-Israel ties The Indicator from Planet Money - Why the U.S. helps pay for Israel's military, the role of the Indo-European language theory in Nazi racial ideology Throughline - The Whiteness Myth, and personal stories of resistance and rescue efforts History's Secret Heroes - Manfred Gans and X Troop and History's Secret Heroes - The Extraordinary Cook Sisters.

The podcast episodes also examine how the legacy of the Holocaust has shaped human rights movements and policies in its aftermath, as explored in Better Human Podcast - The Holocaust, human rights and the dying of the light.