DeepSummary
In this episode, Dr. Tina Moore interviews Dr. Greg Kelly, a fellow naturopathic physician and the vice president of product development at Neurohacker Collective and Qualia. They delve into the topic of senescent cells, also known as "zombie cells," which are cells that have stopped dividing but remain alive, potentially causing harm to the body.
Dr. Kelly explains the causes of cellular senescence, including stress, poor nutrition, and the accumulation of damage over time. He discusses how senescent cells can secrete inflammatory compounds that turn healthy cells into more zombie cells, contributing to various age-related conditions and diseases. The conversation also covers the role of senescent cells in inflammation, joint health, and the potential implications for organ transplantation.
Dr. Kelly introduces senolytics, compounds found in certain plants, such as quercetin and fisetin, that can selectively induce apoptosis (programmed cell death) in senescent cells. He describes the "hit and run" dosing approach used with senolytics, where high doses are taken intermittently to reset the body's sensitivity to these compounds. The episode explores the potential benefits of senolytics in improving joint function, energy levels, and overall well-being.
Key Episodes Takeaways
- Senescent cells, or 'zombie cells,' are cells that have stopped dividing but remain alive, potentially causing harm to the body by secreting inflammatory compounds and turning healthy cells into more zombie cells.
- Factors like stress, poor nutrition, and the accumulation of damage over time can contribute to the buildup of senescent cells in the body, leading to various age-related conditions and diseases.
- Senolytics are plant-based compounds like quercetin and fisetin that can selectively induce apoptosis (programmed cell death) in senescent cells, potentially improving joint health, energy levels, and overall well-being.
- The recommended protocol for using senolytics involves taking high doses for a couple of days, followed by a period of no senolytics, and then repeating the cycle intermittently, allowing the body to reset its sensitivity to these compounds.
- Lifestyle factors like exercise, calorie restriction, and stress management may help prevent the accumulation of senescent cells, while senolytics offer a targeted approach to removing existing senescent cells from the body.
- Neurohacker Collective has conducted pilot studies and placebo-controlled trials on their senolytic product, showing promising results in improving joint function, energy levels, and emotional well-being.
- The concept of senolytics and the removal of senescent cells is a rapidly developing area of research with potential implications for aging, chronic diseases, and overall health and longevity.
- While promising, the use of senolytics is still an emerging field, and more research is needed to fully understand their mechanisms, long-term effects, and optimal protocols for various health conditions.
Top Episodes Quotes
- “So the original work on, like, I guess, around 2010 was, I think, the landmark study. And what they did in that case was they genetically modified animals so that they wouldn't produce senescent cells and noticed that they didn't have many of the issues with aging that other animals had. So, cool. But what do you really do with that information? And then in 2015, Mayo Clinic Scripps Institute of Aging co authored a paper. But the gist of it was they had this idea that, well, there's certain networks of proteins within cells that senescent cells are essentially manipulating to resist going through apoptosis.“ by Doctor Greg Kelly
- “One of the things that we do, Polly, is before we launch a product, we always want to do some kind of what we think of as a pilot study. So these are non placebo controlled, but something where we're testing the whole recipe of things we put together to see if it's improving performance. And since there's no really easy way to say there's no marker you could look at in blood to track with senescent cells, none of the epigenetic plaques are useful for measuring senescent cells. So the area I eventually settled on is where we just look at joint function.“ by Doctor Greg Kelly
- “The key thing is you always want to do it intermittently. So you want to always build in some downtime when you're not doing the senolytic.“ by Doctor Greg Kelly
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Episode Information
The Dr. Tyna Show
Dr. Tyna Moore
4/17/24