DeepSummary
In this episode, Max Lugavere interviews Dr. Charles Brenner, a distinguished biochemist and chair of biochemistry at the University of Iowa. They discuss various aspects of longevity science and the myths surrounding it. Dr. Brenner explains that while mice studies have shed light on the effects of calorie restriction and protein restriction, it is irresponsible to prescribe these practices to all humans. He emphasizes the importance of maintaining skeletal muscle mass and function for healthy aging.
Dr. Brenner talks about the role of nicotinamide adenine dinucleotide (NAD) in cellular metabolism and how it can be disturbed by various factors, including alcohol consumption and inflammation. He discusses the potential benefits of supplementing with NR (nicotinamide riboside) for injury recovery, anti-inflammatory effects, and boosting NAD levels.
The conversation also covers topics such as the lack of dominantly acting longevity genes in humans, the potential trade-offs of testosterone replacement therapy, and the importance of challenging oneself physically and mentally. Dr. Brenner stresses that there are no shortcuts to healthy aging and that sustainable practices, such as exercise, proper sleep, and balanced nutrition, are crucial.
Key Episodes Takeaways
- Calorie restriction and protein restriction should not be universally prescribed, as individual circumstances and goals vary.
- Maintaining skeletal muscle mass and function is crucial for healthy aging.
- There is a potential use case for NR supplementation in injury recovery and anti-inflammatory effects.
- There are no shortcuts or single-gene solutions for longevity; sustainable practices like exercise, sleep, and balanced nutrition are key.
- Consumer-based biomarker tests for aging may not be as meaningful as functional tests of physical and cognitive performance.
- Testosterone replacement therapy may have trade-offs and should be considered carefully.
- Challenging oneself physically and mentally is important for healthy aging.
- While some factors like alcohol can disturb the NAD system, balancing energy intake and expenditure is crucial.
Top Episodes Quotes
- “I don't really think that there's a shortcut.“ by Charles Brenner
- “To me, these functional tests are more important than consumer age kits.“ by Charles Brenner
- “I don't think that dominantly acting longevity genes exist, like the sirtuin genes were described as dominantly acting longevity genes. That's basically been debunked.“ by Charles Brenner
- “I mean, I personally study the dysregulation of the NAD system, and essentially, we found that I could probably name you ten different conditions of metabolic stress, many of which occur to us inevitably, that disturb the NAD system.“ by Charles Brenner
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Episode Information
The Genius Life
Max Lugavere
4/8/24
Charles Brenner, PhD is the chair of the new Department of Diabetes & Cancer Metabolism at the Beckman Research Institute of the City of Hope National Medical Center. He is a major contributor to work on nicotinamide adenine dinucleotide (NAD) metabolism.
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