The concept of metabolic stress is explored in the podcast episodes, particularly in relation to its impact on the NAD system and its role in the aging process.

In Episode 385 of The Genius Life, the host and guest discuss the myths surrounding calorie restriction and protein restriction, and the importance of maintaining skeletal muscle mass for healthy aging. The role of NAD in aging is also highlighted, as well as the potential benefits of NR supplementation.

Similarly, Episode 161 of STEM-Talk focuses on the metabolic stress induced by blood-flow restriction (BFR) training, including factors like lactate accumulation and hypoxia, which are key stimuli for adaptation.