The Armenian Genocide is a central topic across multiple podcast episodes, as it had a profound impact on the region, the displaced populations, and the international humanitarian efforts that followed.

The episode The Armenian Genocide provides a detailed overview of the events, while the episodes Davide Rodogno, "Night on Earth: A History of International Humanitarianism in the Near East, 1918-1930" and Samuel Dolbee, "Locusts of Power: Borders, Empire, and Environment in the Modern Middle East" explore the aftermath and impact of the genocide, including the experiences of Armenian deportees and the role of humanitarian organizations.

The episode Serj Tankian also touches on the Armenian Genocide, as the musician's Armenian heritage and his family's survival story are deeply tied to this historical event.