The podcast episodes discuss the specific brain circuits and regions involved in regulating hunger, appetite, thirst, and other feeding-related behaviors, as well as the rewiring and changes in brain circuits related to mood and reward in the context of ketamine's mechanisms of action.

For example, the episode Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity explains the neural circuitry and hormonal signals that control hunger, appetite, and thirst, providing insights into the obesity epidemic and the development of new anti-obesity medications like GLP-1 agonists. The episode Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity discusses how ketamine causes rewiring of brain circuits to relieve symptoms of depression and other psychiatric challenges by impacting the brain's glutamate and opioid pathways.