The topic of existential dread is explored in several of the podcast episodes, as the hosts and guests grapple with feelings of insignificance, loss of control, and the challenges of finding meaning in the face of the unknown.

In the episode 'No Sleep #1 - Disturbed Patreon Preview', the narrator describes being trapped in an "endless, warped suburban world filled with bizarre anomalies and a sinister, ageless entity," which reflects the fear of being trapped in a reality beyond one's control. Similarly, in the episode '"OUTER SPACE HAS RUINED MY LIFE"', callers express a deep anxiety stemming from contemplating the vastness of the universe and their own insignificance.

The topic of existential dread is further explored in the episode '#287 - Bobby Lee: Comedy, Skyrim, Sex Robots, Love, Fame, and Power', where the conversation delves into profound themes of mortality, ethics, and finding meaning in the face of the finality of death.