The FDA's regulatory role is a key focus across the podcast episodes provided, as it governs the approval, testing, and use of various products, from psychedelic drugs Psychedelics' Long Strange Trip to the Doctor's Office to nicotine pouches Zyn pouches, 'Zynfluencers' and 'the Zyndemic' to abortion medications Opinionpalooza: Don't Call the Mifepristone Case a Win (Preview).

The FDA's oversight and decision-making processes are shown to significantly impact the availability and use of these products, often sparking public health debates and legal challenges that further highlight the agency's central role in regulating the medical and pharmaceutical sectors.